By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer causing agents covers environmentally and occupationally major cancer agents of commercial origins.
The booklet discusses the structure-activity relationships, metabolism, and environmental value of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and similar aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental value of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and comparable compounds thiocarbonyl compounds also are encompassed. The ebook extra tackles the structure-activity relationships, metabolism, and environmental importance if fatty acids, detergents, and different surfactants with oncogenic strength. The textual content then appears to be like into the impression of chemical reactivity, molecular geometry, and metabolism on carcinogenic job.
Chemists, geneticists, and people thinking about melanoma study will locate the ebook worthy.
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Extra resources for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
However, more recent investigations have not provided convincing evidence for its carcinogenicity. Similarly, trichloroethylene has been shown to be carcinogenic in two studies but inactive in seven other studies; the role of possible impurities present in the samples of trichloroethylene used in these studies has not been thoroughly investigated. Technical-grade tetrachloroethylene was reported to induce hepatocellular carcinomas in mice after oral administration, but is tentatively considered inactive in the rat.
In contrast to the 1,1,1-isomer, 1,1,2-trichloroethane was found to be carcinogenic in B6C3Fj mice (264). As seen in Table VIII the compound caused a significant increase in the incidence of hepatocellular carcinomas in mice of both sexes; the high dose was also associated with the induction of pheochromocytoma of the adrenal gland. However, in Osborne-Mendel rats of either sex, no tumors were observed following daily oral doses of 46 or 92 mg/kg, 5 days/week for 78 weeks (Table XV). Two isomers of tetrachloroethane have been tested by the NCI by oral administration.
Cancer Inst. ] All rats were 12 weeks old at the start of the experiment. They were given subcutaneous injections of a 50% solution of CCI/ in corn oil twice a week and were sacrificed when they became moribund. 15 Japanese S train No. of rats at start No. 1 Halogenated Linear Alkanes and Alkenes I 41 In addition to rats and mice, CC14 has been shown to be hepatocarcinogenic in the hamster and in rainbow trout. Delia Porta et al. 5 μΐ CC14 in 5% corn oil solution to 20 (10 of each sex) 12-week-old Syrian golden hamsters.
Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms by Yin-Tak Woo, David Y. Lai, Joseph C. Arcos